Rodrigo B. Andrade

 

andrade

Associate Professor

B.A. (1996), Johns Hopkins University
Ph.D. (2001), Massachusetts Institute of Technology
NIH Postdoctoral Fellow (2003-2005), University of Texas at Austin

OFFICE
Beury Hall 452


MAILING ADDRESS

Department of Chemistry
Beury Hall 130
1901 N. 13th Street
Philadelphia, PA 19122


PHONE

office: 215-204-7155
fax: 215-204-9851

lab: 215-204-3423

E-MAIL
randrade@temple.edu


RESEARCH GROUP

http://chem.cst.temple.edu/~randrade/

Medicinial / Organic

Research Interests

    We are interested in the following general areas of Organic Chemistry:

  • Total Synthesis of Bioactive Natural Products and Analogs Thereof
  • Synthetic Methodology
  • Carbohydrate Chemistry (Methodology, Synthesis)
  • Development of Carbohydrate Based Drugs and Vaccines

 

Selected Publications

Glassford, Ian; Lee, Miseon; Wagh, Bharat; et al. "Desmethyl Macrolides: Synthesis and Evaluation of 4-Desmethyl Telithromycin" ACS Medicinal Chemistry Letters (2014), 5, 9, 1021-1026

 

Mungala, Surendrachary; Sirasani, Gopal; Kokkonda, Praveen; et al. "Synthesis and evaluation of Strychnos alkaloids as MDR reversal agents for cancer cell eradication" Bioorganic & Medicinal a Chemistry (2014), 22, 3, 1148-1155

 

Wagh, Bharat; Paul, Tapas; DeBrosse, Charles, et al. "Desmethyl Macrolides: Synthesis and Evaluation of 4, 8, 10-Tridesmethyl Cethromycin" ACS Medicinal Chemistry Letters (2013), 4, 11, 1114-1118

 

Zhao, Senzhi; Andrade, Rodrigo B. "Domino Michael/Mannich/N-Alkylation Route to the Tetrahydrocarbazole Framework of Asidosperma Alkaloids: Concise Total Syntheses of (-)-Aspidospermidine, (-)-Tabersonine, and (-)-Vincadiffornine" Journal of American Chemical Society (2013), 135, 36, 13334-13337

 

Wagh, Bharat; Paul Tapas; DeBrosse, Charles; Andrade, Rodrigo B. et al. "Desmethyl Macrolides: Synthesis and Evaluation of 4,8,10-Tridesmethyl Cethromycin" ACS Medicinal Chemistry Letters (2013), 4, 11, 1114-1118

 

Zhao, Senzhi; Sirasani, Gopal; Vaddypally, Shivaiah; Andrade, Rodrigo B. et al. "Total Synethsis of (-)-Melotenine A" Angewandte Chemie-International Edition (2013), 52, 32, 8309-8311

 

Kaplan, Justin M.; Shang, Jing; Gobbo, Pierangelo; Andrade, Rodrigo B. et al. "Conformationally Constrained Functional Peptide Monolayers for the Controlled Display of Bioactiv Carbohydrate Ligands" Langmuir (2013), 29, 26, 8187-8192

 

Small, Meagen C.; Lopes, Pedro; Andrade, Rodrigo B.; et al. "Impact of Ribosomal Modification on the Binding of the Antibiotic Telithromycin Using a Combined Grand Canonical Monte Carlo/Molecular Dynamics Simulation Approach" Plos Computational Biology (2013), 9, 6, e1003113

 

Wagh, Bharat; Paul Tapas; Glassford, Ian; Andrade, Rodrigo B.; et al. "Desmethyl Macrolides: Synthesis and Evaluation of 4,8-Didesmethyl Telithromycin" ACS Medicinal Chemistry Letters (2012), 3, 12, 1013-1018

 

Yu, Arthur; Shang, Jing; Cheng, Fang; Paik, Bradford A.; Kaplan, Justin M.; Andrade, Rodrigo B.; Ratner, Daniel M. "Biofunctional Paper via the Covalent Modification of Cellulose" Langmuir (2012), 28, 30, 11265 - 11273

 

Velvadapu, V.; Glassford, I.; Lee, M.; Paul, T.; Debrosse, C.; Klepacki, D.; Small, MC.; Mackerell, AD Jr.; Andrade RB. "Desmethyl Macrolides: Synthesis and Evaluation of 4, 8-Didesmethyl Telithromycin" ACS Medicinal Chemistry Letters (2012), 3, 3, 211 - 215