Associate Dean for Science Education
B.S. (1981) University of Missouri – St. Louis
Analytical / Environmental / Inorganic / Materials
Evaluating Biomarkers of Inflammation of Cardiovascular Risk
The purpose of this research is to understand how gender differences are manifested in cardiac vascular risk. More specifically, are the current clinical risk assessment tools sufficient for therapeutic recommendations? Our hypothesis is that the state of inflammation in cardiac tissues from a variety of metabolic factors and disease provides a more reliable risk assessment tool. Therefore, analytical tools to quantitatively assess the levels of inflammation will be developed; and these methods will be applied to understanding the development of cardiovascular disease and related gender differences using a rat model.
Inflammation in Tumor Progression
We are interested in the molecular mechanisms that regulate tumor progression in colon cancer. Currently we are developing bioanalytical methods to quantify major eicosanoids that regulate inflammation and tumor growth.
Profiling the Course of Hypertensive Disease
Determination of creatinine and 8-iso PGF2 from the same urine sample is efficient. Levels of urinary isoprostane and creatinine are markers of disease progression as is age. In this study, levels of inflammatory biolipids are quantified and correlated with levels of natural sex hormone to profile progression of disease from hypertensive conditions.
Understanding Inflammation in Brain Injury and Disease
We are interested in understand how resolution of inflammation encourages recovered from traumatic brain injury and how the availability of brain active biolipids affects brain function.
“Are the methods equivalent in terms of their accuracy and precision? Comparison of UHPLC and HPLC Methods for the Assay of Prostanoids.” D. Varma; S. Ganti; T. Gilles; M. Diaz; T. Thompson; J. Stull; S.A. Jansen. Bioanalysis. (2011) 3(8): 853-862.
"Development and validation of a stability indicating high-performance liquid chromatography method for the simultaneous analysis of albuterol, budesonide, and ipratropium bromide in extemporaneous compounded nebulizer solutions." A.J. Blewett; S.A. Jansen; D. Varma; T. Gilles; R. Butcher; J. Jacob; J Amazon.. Journal of AOAC International. (2011), 94(1): 1-8.
"Additive enhanced controlled and living free radical polymerization of methacrylates by stabilized nitroxide unimolecular initiaties." O.E. Ansong; S. Jansen; Y. Wei; G. Pomrink; H. Lu; A. Patel; S. Li. Polymer Preprints (ACS). (2009), 49(2): 3-4.
"Accelerated controlled radical polymerization of methacrylates." O.E. Ansong; S. Jansen; Y. Wei; G. Pomrink; H. Lu; A. Patel; S. Li. Polymer Int. (2009), 58(1): 54-65.
"Accelerant-promoted free radical polymerization of methacrylates by stabilized nitroxide unimolecular initiators: synthesis and characterization." O.E. Ansong; S. Jansen; Y. Wei, Polymer International. (2008), 57(6): 863-871.
"Development and validation of a high-performance liquid chromatography-electrospray mass spectrometry method for the simultaneous determination of 23 eicosanoids." A.J. Blewett; D. Varma; T. Gilles; S. Jansen, Journal of Pharmaceutical and Biomedical Analysis. (2008), 46(4): 653-662.
"Novel N-acyloxytrialkylammonium salts as initiators for free radical polymerization of methacrylates." O.E. Ansong; S. Jansen; Y. Wei, Journal of Materials Chemistry. (2007), 17: 4499-4507.
"A liquid chromatography/mass spectrometric method for simultaneous analysis of arachidonic acid and its endogenous eicosanoid metabolites prostaglandins, dihydroxyeicosatrienoic acids, hydroxyeicosatetraenoic acids, and eposyeicosatrienoic acids in rat brain tissue." H.F. Yue; S.A. Jansen; K.L. Strauss, Journal of Pharmaceutical and Biomedical Analysis. (2007), 43(3): 1122-1134.
"Liquid chromatography-mass spectrometric analysis of buprenorphine and its N-dealkylated metabolite norbuprenorphine in rat brain tissue and plasma." H.F. Yue; M.R. Borenstein; S.A. Jansen, Journal of Pharmacological and Toxicological Methods. (2005), 52(3): 314-322.
"Cyclooxygenase-2-specific inhibitor improves functional outcomes, provides neuroprotection, and reduces inflammation in a rat model of traumatic brain injury." J.J. Gopez; H.F. Yue; R. Vasudevan, Neurosurgery. (2005), 56(3): 590-603.
"In vitro tobramycin elution analysis from a novel beta-tricalcium phosphate-silicate-xerogel biodegradable drug-delivery system." M. DiCicco; A. Goldfinger; F. Guirand; S.A. Jansen, Journal of Biomedical Materials Research Part B- Applied Biomaterials. (2004), 70B(1): 1-20.
"Corrosion inhibition by aniline oligomers through charge transfer: a DFT approach." L.T. Sein; Y. Wei; S.A. Jansen, Synthetic Metals. (2004), 143(1): 1-12.