William M. Wuest
B.S. (2003) University of Notre Dame
Ph.D. (2008) University of Pennsylvania
NIH Postdoctoral Fellow (2008-2011), Harvard Medical School
Beury Hall 130
Antibacterial resistance has increased exponentially over the past two decades while the number of new antibiotics with unique modes of action has decreased. My group will examine the new avenues for drug design by utilizing an interdisciplinary approach involving both organic chemistry and biology. More specifically, we will synthesize compounds that can act as both inhibitors and probes and investigate how they affect chemical signaling in pathogenic bacteria. This approach should identify new biological targets and compounds for antibacterial drug discovery.
For more details and images see our research page.
Imker, H.J.; Walsh, C.T.; Wuest, W.M. "SylC Catalyzes Ureido-Bond Formation During Biosynthesis of the Proteasome Inhibitor Syringolin A." J. Am. Chem. Soc. 2009. 131, 18263.
Wuest, W.M.; Sattely, E.S.; Walsh, C.T. "Three Siderophores from One Bacterial Enzymatic Assembly Line." J. Am. Chem. Soc. 2009. 131, 5056.
Smith III, A.B.; Cox, J.M.; Furuichi, N.; Kenesky, C.S.; Zheng, J.; Atasoylu, O.; Wuest, W.M. "Evolution of Multi-Component Anion Relay Chemistry (ARC): Construction of Architecturally Complex Natural and Unnatural Products." Org. Lett. 2008. 45, 5883.
Smith III, A.B.; Kim, W.S.; Wuest, W.M.; "Ortho-TMS Benzaldehyde: an Effective Linchpin for Type II Anion Relay Chemistry (ARC)." Angew. Chem. Int. Ed. 2008. 47, 7082.
Carney, J.M.; Donoghue, P.J.; Wuest, W.M.; Wiest, O.; Helquist, P. "Intramolecular Hydroamination of Aminoalkynes with Silver Phenanthroline Catalysts." Org. Lett. 2008. 10, 3903.