The overarching goal of the Wuest research group is to utilize chemical biology to perturb bacterial biofilm processes, which effect everything from human health to water purification. Our group implements a variety of methods to interrogate the signaling process with the overarching goal of identifying novel treatments and new targets for pharmaceutical development. Nationally, only a few synthetic endeavors have approached this problem in a similar way thus positioning our group for therapeutic breakthroughs. Currently, we are using synthetic organic chemistry and chemical genetic approaches to target known natural product biofilm inhibitors, signaling molecules, and protein-protein interactions. In conjunction, we are also using microbiological and biochemical approaches to discover new therapeutics, identify unprecedented biological targets, and test the efficacy of compounds developed in house.
Steele, A.D.; Keohane, C.E.; Knouse, K.W.; Rossiter, S.E.; Williams, S.J.; Wuest, W.M.* “Diverted Total Synthesis of Promysalin Analogs Demonstrates that an Iron-Binding Motif is Responsible for its Narrow-spectrum Antibacterial Activity” J. Am. Chem. Soc. 2016 138, 5833
Mitchell, M.A.; Iannetta, A.A.; Jennings, M.C.; Fletcher, M.H.; Wuest, W.M.*; Minbiole, K.P.C.* “Scaffold-hopping of Multicationic Amphiphiles Yields Three New Classes of Antimicrobials” ChemBioChem 2015 16, 2299. (highlighted as a Very Important Paper)
Steele, A.D.; Knouse, K.W.; Keohane, C.E.; Wuest, W.M.* “Total Synthesis and Biological Evaluation of (-)-Promysalin” J. Am. Chem. Soc. 2015 137, 7314.
Jennings, M.C.; Buttaro, B.A.; Minbiole, K.P.C.; Wuest, W.M.* “Bioorganic Investigation of Multicationic Antimicrobials to Combat QAC-Resistant Staphylococcus aureus” ACS Infectious Diseases, 2015 1, 304.
Hallside, M.S.; Brzozowski, R.S.; Wuest, W.M.*; Phillips, A.J.* “A Concise Synthesis of Carolacton” Org. Lett. 2014 16, 1148.