Specialties
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Biography
InterestsResearch in the Andrade Laboratory is inspired by Nature's unrivaled capacity to produce myriad, complex chemical structures that possess unique biological activities. We develop novel synthetic methodology to efficiently prepare structures of interest (i.e., synthesis), interrogate their molecular mechanisms of action in biological systems (i.e., chemical biology), and apply our findings to develop therapeutics (i.e., medicinal chemistry).
Current projects include the discovery of (1) novel macrolide-based antibiotics that address the problem bacterial resistance and (2) indole alkaloids that combat cancer via unique mechanisms of action. Select PublicationsYu, P.-C.; Chatare, V. J.; Patel, H.; DeBrosse, C.; Andrade, R. B. The vinylogous aldol reaction of N-sulfinyl metallodienamines. Tetrahedron 2020, 76, 130901 (e-article)
Kokkonda, P.; Andrade, R. B. Total synthesis of (+)-epi-condyfoline. Org. Lett. 2019, 21, 9594-9597 Daher, S. S.; Jin, X.; Patel, J.; Freundlich, J. S.; Buttaro, B.; Andrade, R. B. Synthesis and Biological Evaluation of Solithromycin Analogs Against Multidrug Resistant Pathogens. Bioorg. Med. Chem. Lett. 2019, 29, 1386-1389 Zhao, S.; Teijaro, C. N.; Chen, H.; Sirasani, G.; Vaddypally, S.; Zdilla, M. J.; Dobereiner, G. E.; Andrade, R. B. Asymmetric chemical syntheses of Bis-Strychnos Alkaloids: (–)-Sungucine, (–)-Isosungucine, and (–)-Strychnogucine B. J. Braz. Chem. Soc. 2018, 30, 436–453. Jin, X.; Daher, S. S.; Lee, M.; Buttaro, B.; Andrade, R. B. Ribosome-templated azide-alkyne cycloadditions using resistant bacteria as reaction vessels: in cellulo click chemistry. ACS Med. Chem. Lett. 2018, 9, 907-911. Liang, H.; Zhou, G.; Ge, Y.; D’Ambrosio, E. Z.; Eidem, T. M.; Blanchard, C.; Shehatou, C.; Chatare, V. K.; Dunman, P. M.; Valentine, A. M.; Voelz, V. A.; Grimes, C. L.; Andrade, R. B. Elucidating the inhibition of peptidoglycan biosynthesis in Staphylococcus aureus by albocycline, a macrolactone isolated from Streptomyces maizeus. Bioorg. Med. Chem. 2018, 26, 3453-3460. Chatare, V. K.; Andrade, R. B. Total synthesis of (–)-albocycline. Angew. Chem. Int. Ed., 2017, 56, 5909–5911. Zhao, S.; Andrade, R. B. The Development and Application of the Domino Michael/Mannich/N-Alkylation Route to the Total Syntheses of Aspidosperma Alkaloids: Asymmetric Total syntheses of (–)-Aspidospermidine, (–)-Tabersonine, and (–)-Vincadifformine. J. Org. Chem. 2017, 82, 521–531. Zhao, S.; Teijaro, C. N.; Chen, H.; Sirasani, G.; Vaddypally, S.; Zdilla, M.; Dobereiner, G. E.; Andrade, R. B. Concise Syntheses of Bis-Strychnos Alkaloids (–)-Sungucine, (–)-Isosungucine, and (–)-Strychnogucine B from (–)-Strychnine. Chem. Eur. J. 2016, 22, 11593–11596. Glassford, I.; Teijaro, C. N.; Daher, S. S.; Weil, A.; Small, M. C.; Redhu, S. K.; Colussi, D. J.; Jacobson, M. A.; Childers, W. E.; Buttaro, B.; Nicholson, A. W.; MacKerell, A. D. Jr., Cooperman, B. S.; Andrade, R. B. Ribosome-templated azide−alkyne cycloadditions: synthesis of potent macrolide antibiotics by in situ click chemistry. J. Am. Chem. Soc., 2016, 138, 3136–3144. |
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