Research in our lab lies at the interface of chemistry and biology, with an eye towards understanding and treating human diseases. We use interdisciplinary approaches such as organic synthesis, chemical proteomics, protein engineering, chemical sensing, and molecular imaging to investigate the biological mechanisms underlying diseases such as cancer, inflammation, and immune disorders. In particular, we are interested in developing innovative probes to systematically dissect proteins essential for the onset and relapse of diseases. We are also actively pursuing the design and synthesis of novel diagnostics and therapeutics, using our expertise in protein engineering, organic synthesis, drug delivery, library screening, and cell assay. Students have the opportunity to work in may areas spanning from organic synthesis to molecular biology/cell biology. The training is expected to help students achieve multiple skill sets and a strong publication record.
A Switchable Site-Specific Antibody Conjugate.
Lyu Z, Kang L, Buuh ZY, Jiang D, McGuth JC, Du J, Wissler HL, Cai W, Wang RE.
ACS Chem Biol. 2018 Apr 20;13(4):958-964.
Interrogating the Roles of Post-Translational Modifications of Non-Histone Proteins.
Buuh ZY, Lyu Z, Wang RE.
J Med Chem. 2018 Apr 26;61(8):3239-3252
Rational design of a Kv1.3 channel-blocking antibody as a selective immunosuppressant
Wang RE, Wang Y, Zhang Y, Gabrelow C, Zhang Y, Chi V, Fu Q, Luo X, Wang D, Joseph S, Johnson K, Chatterjee AK, Wright TM, Nguyen-Tran VT, Teijaro J, Theofilopoulos AN, Schultz PG, Wang F
Proc. Natl. Acad. Sci. USA. 2016, 113(41):11501-11506
An immunosuppressive antibody-drug conjugate
Wang RE, Liu T, Wang Y, Cao Y, Du J, Luo X, Deshmukh V, Kim CH, Lawson BR, Tremblay MS, Young TS, Kazane SA, Wang F, Schultz PG
J. Am. Chem. Soc. 2015, 137(9):3229-32
A homogeneous fluorescent sensor for human serum albumin
Wang RE, Tian L, Chang YH
J. Pharm. Biomed. Anal. 2012, 63:165-9
Biotinylated quercetin as an intrinsic photoaffinity proteomics probe for the identification of quercetin target proteins
Wang RE, Hunt CR, Chen J, Taylor JS
Bioorg. Med. Chem. 2011, 19(16):4710-20
Inhibition of heat shock induction of heat shock protein 70 and enhancement of heat shock protein 27 phosphorylation by quercetin derivatives
Wang RE, Kao JL, Hilliard CA, Pandita RK, Roti Roti JL, Hunt CR, Taylor JS
J. Med. Chem. 2009, 52(7):1912-21