Research in our lab lies at the interface of chemistry and biology, with an eye towards understanding and treating human diseases. We use interdisciplinary approaches such as organic synthesis, chemical proteomics, protein engineering, chemical sensing, and molecular imaging to investigate the biological mechanisms underlying diseases such as cancer, inflammation, and immune disorders. In particular, we are interested in developing innovative probes to systematically dissect proteins essential for the onset and relapse of diseases. We are also actively pursuing the design and synthesis of novel diagnostics and therapeutics, using our expertise in protein engineering, organic synthesis, drug delivery, library screening, and cell assay. Students have the opportunity to work in may areas spanning from organic synthesis to molecular biology/cell biology. The training is expected to help students achieve multiple skill sets and a strong publication record.
Site-specific antibody fragment conjugates for targeted imaging.
Maloney R, Buuh ZY, Zhao Y, Wang RE. Methods Enzymol. 2020;638:295-320.
A tumor-targeted immune checkpoint blocker
Zhang Y, Fang C, Wang RE, Wang Y, Guo H, Guo C, Zhao L, Li S, Li X, Schultz PG, Cao YJ, Wang F. Proc Natl Acad Sci U S A. 2019 Aug 6;116(32):15889-15894.
Site-Specific Immuno-PET Tracer to Image PD-L1.
Wissler HL, Ehlerding EB, Lyu Z, Zhao Y, Zhang S, Eshraghi A, Buuh ZY, McGuth JC, Guan Y, Engle JW, Bartlett SJ, Voelz VA, Cai W, Wang RE. Mol Pharm. 2019 May 6;16(5):2028-2036.
A Switchable Site-Specific Antibody Conjugate.
Lyu Z, Kang L, Buuh ZY, Jiang D, McGuth JC, Du J, Wissler HL, Cai W, Wang RE.
ACS Chem Biol. 2018 Apr 20;13(4):958-964.
Interrogating the Roles of Post-Translational Modifications of Non-Histone Proteins.
Buuh ZY, Lyu Z, Wang RE.
J Med Chem. 2018 Apr 26;61(8):3239-3252