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Rongsheng (Ross) Wang

Assistant Professor
Biological, Organic
Office: SERC 642
Phone: 215-204-1855​
Send an email
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Biography

2012-2016

2010

2005

Selected Awards
Postdoctoral researcher, The Scripps Research Institute

Ph.D. Washington University in St Louis

B.S. Nanjing University 

Scialog Fellow 2019. NIH MIRA award. CCSG Pilot Research Award, Fox Chase Cancer Center.  IRG Award, American Cancer Society.  Leukemia SPORE Career Enhancement Award.

Interests

Research in our lab lies at the interface of chemistry and biology, with an eye towards understanding and treating human diseases.  We use interdisciplinary approaches such as organic synthesis, chemical proteomics, protein engineering, chemical sensing, and molecular imaging to investigate the biological mechanisms underlying diseases such as cancer, inflammation, and immune disorders.  In particular, we are interested in developing innovative probes to systematically dissect proteins essential for the onset and relapse of diseases.  We are also actively pursuing the design and synthesis of novel diagnostics and therapeutics, using our expertise in protein engineering, organic synthesis, drug delivery, library screening, and cell assay.  Students have the opportunity to work in may areas spanning from organic synthesis to molecular biology/cell biology.  The training is expected to help students achieve multiple skill sets and a strong publication record.    

Select Publications

A Switchable Site-Specific Antibody Conjugate.
Lyu Z, Kang L, Buuh ZY, Jiang D, McGuth JC, Du J, Wissler HL, Cai W, Wang RE.
ACS Chem Biol. 2018 Apr 20;13(4):958-964. 

Interrogating the Roles of Post-Translational Modifications of Non-Histone Proteins.
Buuh ZY, Lyu Z, Wang RE.
J Med Chem. 2018 Apr 26;61(8):3239-3252
​
Rational design of a Kv1.3 channel-blocking antibody as a selective immunosuppressant

Wang RE, Wang Y, Zhang Y, Gabrelow C, Zhang Y, Chi V, Fu Q, Luo X, Wang D, Joseph S, Johnson K, Chatterjee AK, Wright TM, Nguyen-Tran VT, Teijaro J, Theofilopoulos AN, Schultz PG, Wang F    
Proc. Natl. Acad. Sci. USA. 2016, 113(41):11501-11506
 
An immunosuppressive antibody-drug conjugate
​Wang RE, Liu T, Wang Y, Cao Y, Du J, Luo X, Deshmukh V, Kim CH, Lawson BR, Tremblay MS, Young TS, Kazane SA, Wang F, Schultz PG
J. Am. Chem. Soc. 2015, 137(9):3229-32

A homogeneous fluorescent sensor for human serum albumin
Wang RE, Tian L, Chang YH
J. Pharm. Biomed. Anal. 2012, 63:165-9

Biotinylated quercetin as an intrinsic photoaffinity proteomics probe for the identification of quercetin target proteins
Wang RE, Hunt CR, Chen J, Taylor JS
Bioorg. Med. Chem. 2011, 19(16):4710-20

Inhibition of heat shock induction of heat shock protein 70 and enhancement of heat shock protein 27 phosphorylation by quercetin derivatives
Wang RE, Kao JL, Hilliard CA, Pandita RK, Roti Roti JL, Hunt CR, Taylor JS
J. Med. Chem. 2009, 52(7):1912-21

TEMPLE UNIVERSITY
COLLEGE OF SCIENCE AND TECHNOLOGY
DEPARTMENT OF chemistry

Department of Chemistry
Temple University
1901 N. 13th St.
Philadelphia, PA 19122
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