Our lab aims to develop a multifaceted research program focusing on asymmetric methods development and natural product synthesis as the means for fueling biological investigations. Our research program will provide students with training across multiple scientific fields and aid in their understanding of the interplay between chemistry and biology. Representative research areas include C–H activation, asymmetric C–C bond formation, novel methods to access carbon, oxygen, and nitrogen containing ring systems, and the synthesis of natural products targeting cancer metastasis.
Hypervalent Iodine Reagents in High Valent Transition Metal Chemistry
Cesar Sousa e Silva, F.; Tierno, A. F.; Wengryniuk S. E.
Molecules 2017, 22(5), 780.
Access to Diverse Oxygen Heterocycles via Oxidative Rearrangement of Benzylic Tertiary Alcohols
Kelley, B. T.; Walters, J. C.; Wengryniuk, S. E.
Org. Lett. 2016, 18, 1896.
11-Step Total Synthesis of Pallambins C and D
Martinez, L. P.; Umemiya, S.; Wengryniuk, S. E.; Baran, P. S.
J. Am. Chem. Soc. 2016, 138, 7536.
Regioselective Asymmetric α,α-Bisalkylation of Ketones via Complex Induced Syn-Deprotonation of Chiral N-Amino Cyclic Carbamate Hydrazones
Wengryniuk, S. E.; Lim, D.; Coltart, D. M.
J. Am. Chem. Soc. 2011, 133, 8714.