Our lab aims to develop a multifaceted research program focusing on asymmetric methods development and natural product synthesis as the means for fueling biological investigations. Our research program will provide students with training across multiple scientific fields and aid in their understanding of the interplay between chemistry and biology. Representative research areas include C–H activation, asymmetric C–C bond formation, novel methods to access carbon, oxygen, and nitrogen containing ring systems, and the synthesis of natural products targeting cancer metastasis.
Sousa e Silva, F. C., Van, N. T., Wengryniuk, S. E. Direct C–H Alpha-Arylation of Enones with ArI(O2CR)2 Reagents. J. Am. Chem. Soc. 2020, 142, 1, 64.
Xiao, X., Greenwood, N. S., Wengryniuk, S. E. Dearomatization of Electron-Deficient Phenols to ortho-Quinones Enabled by Bidentate Nitrogen-Ligated I(V) Reagents. Angew. Chem. Int. Ed. 2019, 58, 16181-16187.
Mikhael, M., Adler, S. A., Wengryniuk, S. E. Chemoselective Oxidation of Equatorial Alcohols with N-Ligated Lambda-3 Iodanes. Org. Lett, 2019, 21, 5889–5893.
Walters, J. C., Tierno, A. F., Dubin, A. H., Wengryniuk, S. E. (Poly)cationic lambda3-Iodane Mediated Oxidative Ring Expansion of Secondary Alcohols. Eur. J. Org. Chem. 2018, 1460-1464.